Marcell D. Cadney, PhD
Hello and welcome 👋. I am an evolutionary biologist interested in the intersection of evolution, epigenetics, and physiology. I am currently in the University of California President's Postdoctoral Fellowship Program (UC PPFP) at UC Santa Barbara, where I am working on a number of projects.
I am specifically interested in studying the epigenetic components involved in early-life effects, the development of complex traits, how those components evolve, and how they might affect the evolution of complex traits. I employ a number of experimental approaches centered on evolutionary physiology in mice to help address these topics.
I am also interested in the evolution of the human brain and have taken a comparative approach in that respect.
Finally, future projects may take the form of "assisted evolution," where selective breeding (i.e., my PhD work), epigenetic programming (i.e., my Postdoc work), and microbiome transplants (again, my PhD work) can be used to rehabilitate threatened and endangered species in the face of accelerating climate change.
Find out more about my research with these brief summaries.
As a hobby, I make 3D models in Blender. Sometimes I even finish a project! Check it out!
Latchney, S. E., M. D. Cadney, A. Hopkins, and T. Garland Jr. 2022. Next-generation bisulfite sequencing analysis of imprinted genes in the cortex and hippocampus of cross-fostered mice selectively bred for increased voluntary wheel running. Behavior Genetics. In Review
Cadney, M. D., R. L. de Albuquerque, N. L. Schwartz, M. P. McNamara, A. A. Castro, M. P. Schmill, and T. Garland, Jr. 2022. Effects of early-life exposure to fructose and voluntary exercise on adult activity levels, body composition, exercise physiology, and associated traits in mice. JDOHaD. In Review
McNamara, M. P., M. D. Cadney, A. A. Castro, D. A. Hillis, K. M. Kallini, J. C. Macbeth, M. P. Schmill, N. E. Schwartz, A. Hsiao, and T. Garland Jr. 2022. Oral antibiotics reduce voluntary exercise behavior in athletic mice. Behavioural Processes 199:104650. PDF
Cadney, M. D., N. E. Schwartz, M. P. McNamara, M. P. Schmill, A. A. Castro, D. A. Hillis, and T. Garland. 2021. Cross-fostering selectively bred high runner mice affects adult body mass but not voluntary exercise. Physiology & Behavior 241:113569. PDF
Cadney, M. D., L. Hiramatsu, Z. Thompson, M. Zhao, J. C. Kay, J. M. Singleton, R. L. de Albuquerque, M. P. Schmill, W. Saltzman, and T. Garland. 2021. Effects of early-life exposure to Western diet and voluntary exercise on adult activity levels, exercise physiology, and associated traits in selectively bred High Runner mice. Physiology & Behavior 234:113389. PDF
McNamara, M. P., J. M. Singleton, M. D. Cadney, P. M. Ruegger, J. Borneman, and T. Garland, Jr. 2021. Early-life effects of juvenile Western diet and exercise on adult gut microbiome composition in mice. Journal of Experimental Biology 224:jeb239699. PDF
Schmill, M. P., M. D. Cadney, Z. Thompson, L. Hiramatsu, R. L. Albuquerque, M. P. McNamara, A. A. Castro, J. C. Kay, D. G. Buenaventura, J. L. Ramirez, J. S. Rhodes, and T. Garland, Jr. 2021. Conditioned place preference for cocaine and methylphenidate in female mice from lines selectively bred for high voluntary wheel‐running behavior. Genes, Brain and Behavior 20. PDF
Garland, Jr., T., M. D. Cadney, and R. A. Waterland. 2017. Early-life effects on adult physical activity: concepts, relevance, and experimental approaches. Physiological and Biochemical Zoology 90:1–14. PDF